Dermeva CollagenicBoost™ GHK-CU Serum V2

GHK-Cu is a naturally-occurring copper tripeptide your body uses to signal skin repair — levels peak in your twenties and fall by more than 60% by age 60. Applied topically, it acts as a messenger that tells fibroblasts to rebuild collagen and elastin, raises the skin's own antioxidant defenses, and shifts damaged tissue toward healthier, better-organized matrix. Three decades of peer-reviewed research make it one of the most rigorously studied anti-aging molecules in cosmetic science — with documented improvements in firmness, fine lines, clarity, and sun-damage markers.

Ingredients in this blend

Copper Tripeptide-1 (GHK-Cu) 0.1%, Copper PCA

Studies (7)

1. [1]GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

   A 2015 review in BioMed Research International mapping GHK's effect on more than 4,000 human genes. The tripeptide switched repair-related genes on and damage-related genes off, producing measurable improvements in firmness, clarity, and fine lines across multiple clinical datasets.

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2. [2]Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

   Published in the International Journal of Molecular Sciences (2018), this review demonstrated that GHK-Cu reverses gene-expression patterns associated with aged and UV-damaged skin — activating wound-healing pathways while suppressing chronic inflammatory signals.

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3. [3]Stimulation of Collagen Synthesis by the Tripeptide-Copper Complex Glycyl-L-Histidyl-L-Lysine-Cu²⁺

   The foundational 1988 FEBS Letters paper by Maquart et al. — the first to prove GHK-Cu directly triggers fibroblasts to produce new collagen in a dose-dependent manner. The effect was specific to the copper-bound form and did not occur with the free peptide.

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4. [4]The Human Tri-Peptide GHK and Tissue Remodeling

   Loren Pickart's definitive 2008 review in the Journal of Biomaterials Science summarizing three decades of research: GHK levels fall sharply with age, and topical replacement restores the skin's ability to remodel itself — rebuilding dermal thickness, elasticity, and capillary networks.

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5. [5]Expression of Glycosaminoglycans and Small Proteoglycans in Wounds: Modulation by GHK-Cu

   A 2000 Journal of Investigative Dermatology study showing GHK-Cu specifically upregulates decorin — a proteoglycan essential for organized, non-scarring collagen assembly. The finding explains why GHK-Cu improves skin texture rather than simply thickening it.

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6. [6]Effects of a Copper-Binding Peptide Cream Compared with Tretinoin on Skin Ultrastructure

   A 1998 controlled trial (Abdulghani et al.) that compared a GHK-Cu cream to prescription tretinoin using electron microscopy. After 12 weeks the copper peptide produced measurable epidermal thickening and improved collagen organization — comparable to tretinoin on several measures, without the irritation.

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7. [7]Skin Care Benefits of Copper Peptide Containing Facial Cream

   A 12-week double-blind study (Leyden et al., presented at the American Academy of Dermatology) on women with photoaged skin. Participants using a GHK-Cu facial cream showed statistically significant improvements in fine lines, wrinkle depth, skin density, and hydration versus vehicle control.

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